Recruited by the US government for their unique ability to lie, cheat and fight, Amy (Sara Foster), Max (Meagan Good), Janet (Jill Richie) and Dominique (Devon Aoki) join an underground academy of secret agents known only as D.E.B.S. These crime fighting hotties set out to save the world and keep their lipstick perfectly applied while doing so. Now the girls must combine their skills for their most important mission - to capture vexing vixen Lucy Diamond (Jordana Brewster), the deadliest criminal the world has ever known. When D.E.B.S. star player, Amy, falls for Lucy, chaos erupts and the D.E.B.S. loyalty is put to the test.